朱国磊 副教授

导师资格：硕士生导师

招生专业：生物与医药、化学、林产化工、材料与化工

研究方向：天然药物化学

邮箱：guoleizhu@163.com

教育/工作经历

2016年-至今 西南林业大学

2013年-2016年 中科院昆明植物研究所，获博士学位

2010年-2013年 昆明理工大学，获硕士学位

2006年-2010年 昆明理工大学，获学士学位

科研工作及成果

主要致力于植物及其内生真菌中可用于拮抗肿瘤、炎症和病害菌新颖骨架分子的挖掘，结构修饰、构效关系和作用机制等相关研究。旨在获得活性显著、低毒高效的先导化合物，为创新药物开发提供物质基础。作为主持人获得相关项目经费支持，一项国家自然科学基金（地区项目）；一项“兴滇英才”青年人才支持项目；及三项云南省科技厅基础研究等项目。发表论文50余篇，1作或通讯作者20余篇，部分研究成果发表在ACS J. Nat. Prod.，Chin. J. Nat. Med., Fitoterapia, Tetrahedron, Steroids和 Nat. Prod. Bio.等国际刊物。目前课题组已建立成熟的天然产物分离、结构鉴定及活性研究平台；拥有良好的科研助理、博、硕士及本科生研究梯队，研究氛围积极融洽；硕士毕业生均有1作发表SCI论文1-3篇，部分学生能顺利升学攻读博士研究生。

奖励及荣誉称号

2024，云南省自然科学技术三等奖(排名第4)。

代表性论文

(1) Yao, Jiao; Huang, Sai; He, Lingfeng; Wei, Shengyun; Yang, Wei; Zhang, Qiangxin; Wang, Weihua; Yang, Xiaoqin; Xie, Sida; Li, Yunxian; Zhao, Ping; Zhu, Guolei*. Antifungal Polyacetylenic Deoxyglycosides Isolated from Endophytic Fungus Xylaria sp. VDL4 Associated with Vaccinium dunalianum. Journal of Fungi, 2025, 11(3): 209.

(2) Zhang, Zhi-Yu; Fu, Xiao-Man; Shu, Yuan-Cao; Qin, Xu-Jie; Zhang, Ying-Jun; Zhao, Ping; Yang, Xiao-Qin; Zou, Li-Hua; Wang, Wei-Hua; Zhu, Guo-Lei*, Three new compounds of Umbelopsis dimorpha VDG10, a dominant endophytic fungus from Vaccinium dunalianum Wight. Fitoterapia, 2025, 181: 106358.

(3) Fu Xiaoman, Shu Yuancao, Zhang Zhiyu, Wang Weihua, Xie Sida, Yang Xiaoqin, Zhang Yingjun, Zhao Ping*, Zhu Guolei*. Novel sesquiterpenoids from Colletotrichum camelliae LP76, a predominant endophytic fungus from Camellia taliensis, Natural Product Research, 2025, 10.1080/14786419.2025.2490042

(4) Wang, Wei-Hua; Yang, Wei; Dong, Jin-Run; Yang, Fa-Zhong; Chen, Xiao-Tao; Xie, Si-Da; Yang, Xiao-Qin; Zhao, Ping*; Zhu, Guo-Lei*. Toonanoronoids A-E, five new limonoids from Toona ciliata var. yunnanensis. Fitoterapia, 2024, 175: 105938.

(5) Wang, Wei-Hua; Li, Chu-Ran; Qin, Xu-Jie; Yang, Xiao-Qin; Xie, Si-Da; Jiang, Qian; Zou, Li-Hua; Zhang, Ying-Jun; Zhu, Guo-Lei*; Zhao, Ping*. Novel Alkaloids from Aspergillus fumigatus VDL36, an Endophytic Fungus Associated with Vaccinium dunalianum. Journal of Agricultural and Food Chemistry, 2024, 72(19): 10970-10980.

(6) Wang, Wei-Hua; Li, Cai-Ping; Yang, Wei; Dong, Jin-Run; Yang, Fa-Zhong; Xie, Si-Da; Zhao, Ping*; Zhu, Guo-Lei*. Tociliatonoid B-E, novel limonoids from Toona ciliata var. yunnanensis. Tetrahedron, 2024, 154(154): 133888.

(7) Wei-Hua, Wang; Ling-Feng, He; Cai-Ping, Li; Fa-Zhong, Yang; Xiao-Qin, Yang; Si-Da, Xie; Ping, Zhao*; Guo-Lei, Zhu*. Tociliatonoid A: A novel limonoid from Toona ciliata. Tetrahedron Letters, 2022, 113: 154254.

(8) Zhu, Guo-Lei; Hao, Qian; Xing, Liu; Yang, Xiao-Qin; Xie, Si-Da; Zhao, Ping*; Li, Hai-Zhou*. C-21, C-22 pregnane glycosides and cytotoxic C-27 spriostanol steroids from Asparagus cochinchinesis. Steroids, 2021, 172: 108874.

(9) Zhu, Guo-Lei; Wan, Luo-Sheng; Peng, Xing-Rong; Shi, Qiang-Qiang; Li, Xiao-Nian; Chen, Jian-Chao; Zhou, Lin; Qiu, Ming-Hua*. Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata. Journal of Natural Products, 2019, 82(9): 2419-2429.

(10) Zhu, Guo-Lei; Nian, Yin; Zhu, Di-Fan; Wan, Luo-Sheng; Bao, Ni-Man; Wang, Wei-Hua; Zhou, Lin; Qiu, Ming-Hua*. Cytotoxic 9,19-cycloartane triterpenoids from the roots of Cimicifuga foetida L. Phytochemistry Letters, 2016, 18: 105-112.

(11) Zhu Guo Lei; Di Fan Zhu; Luo Sheng Wan; Xing Rong Peng; Ni Man Bao; Zhi Run Zhang; Lin Zhou; Ming Hua Qiu, Six New 9,19-Cycloartane Triterpenoids from Cimicifuga foetida L. Natural Products and Bioprospecting, 2016, 6(4): 187-193.

(12) Zhu Guo-Lei; Hao Qian; Li Rong-Tao; Li Hai-Zhou*. Steroidal saponins from the roots of Asparagus cochinchinensis. Chinese Journal of Natural Medicines, 2014, 12(3): 213-217.